P-017 Validation of origami microscope “Foldscope” as a preliminary screening tool for male infertility

Abstract Study question Is there a concordance between the new optical microscope based on origami (Foldscope) with traditional for semen analysis as screening method? Summary answer There is 91% direct foldscope and initial approximation to male infertility. What known already Semen key element men fertility evaluation. In order obtain sample, patients have assist clinic where sample analyzed. However, due either time or distance problems, many cannot attend clinics. On other hand, Foldscope an origami-based that can provide over 2000x magnification, it be attached smartphone take photos videos, which sent specialists analysis. This technology might important information about status, especially in areas limited care access. design, size, duration A retrospective observational study was carried out, we included samples obtained by masturbation from volunteers were analyzed count, concentration, motility who undergoing November 2021 2022 Clínica Alemana, Santiago, Chile. Participants/materials, setting, methods total of 188 human evaluated single embryologist under standard later used same make cell phone video Foldscope. randomized videos subsequently blindly. Finally, matching results out. Main role chance Moderate significant positive correlation concentration calculated > < 15 million/ml Conventional Microscopy (correlation coefficient= 0.67, p 0.005) Sperm progressives A+B recorded demonstrated coefficient = 0.69, 0.005). sperm count both 91%, kappa index 0.66 (p 0.0001). Limitations, reasons caution One most limitations must interpreted embryologist, means images specialized center. Wider implications findings countries few economic resources not options reproductive medicine centers, use allows quick economical immediate referral problems. Trial registration number applicable